Peer-Reviewed Research Articles
45. Hossain, S.; Heckler, I.; Boon, E.M.* (2018) Discovery of a nitric oxide responsive quorum sensing circuit in Vibrio cholera. American Chemical Society Chemical Biology, 13, 1964–1969 (DOI: 10.1021/acschembio.8b00360).
44. Williams, D.E.; Nisbett, L.M.; Bacon, B.A.; Boon, E.M.* (2017) Bacterial heme-based sensors of nitric oxide. Forum issue themed “Metallocofactors in Sensing,” Booker, S.J., ed. In Antioxidants and Redox Signaling. (DOI: 10.1089/ars.2017.7235).
43. Hossain, S.; Nisbett, L.M.; Boon, E.M.* (2017) Discovery of two bacterial nitric oxide-responsive proteins and their roles in bacterial biofilm regulation. Accounts of Chemical Research, 50, 1633-1639 (DOI: 10.1021/acs.accounts.7b00095). PMCID: PMC5654536
42. Bacon, B.A.; Nisbett, L.M.; Boon, E.M.* (2017) Bacterial haemoprotein sensors of NO: H-NOX and NosP. Themed issue “Metals and Antimicrobials,” Poole, R., ed. Advances in Microbial Physiology, 70, 1-36 (DOI: 10.1016/bs.ampbs.2017.01.004). PMCID: PMC5659832
41. Hossain, S.; Boon, E.M.* (2017) NosP: Discovery of a novel nitric oxide binding protein and nitric oxide-responsive signaling pathway in Pseudomonas aeruginosa. American Chemical Society Infectious Diseases, 3, 454-461 (DOI: 10.1021/acsinfecdis.7b00027). PMCID: PMC5468770
**Cited by the Faculty of 1000 (http://f1000.com/727368716).
**ACS Editor’s choice selection
**Featured on the cover
**3rd most read article in 2017
40. Fischer, J.T.; Johnson, R.A.; Boon, E.M.* (2016) Quantification of bacterial histidine kinase autophosphorylation using a nitrocellulose binding assay. Journal of Visualized Experiments, 119, e55129 (DOI: JoVE55129R1).
39. Nisbett, L.M.; Boon, E.M.* (2016) Nitric oxide regulation of H-NOX signaling pathways in bacteria. Biochemistry, 55, 4873-4884 (DOI: 10.1021/acs.biochem. 6b00754).
38. Sun, Y.; Benabbas, A.; Zeng, W.; Muralidharan, S.; Boon, E.M., Champion, P.M. (2016) Kinetic control of O2 reactivity in H-NOX domains. Physical Chemistry B, 120, 5351-5358 (DOI: 10.1021/acs.jpcb.6b03348).
37. Ueno, T.B.; Johnson, R.A.; Boon, E.M.* (2015) Optimized assay for the quantification of histidine kinase autophosphorylation. Biochemical and Biophysical Research Communications, 465, 331-337 (DOI: 10.1016/j.bbrc.2015.07.121).
36. Arora, D.P.; Hossain, S.; Xu, Y.; Boon, E.M.* (2015) Nitric oxide regulation of bacterial biofilms. Biochemistry, 54, 3717-3728 (DOI: 10.1021/bi501476n).
35. Nesbitt, N.M.; Arora, D.P.; Johnson, R.A.; Boon, E.M.* (2015) Modification of a bi-functional diguanylate cyclase-phosphodiesterase to efficiently produce cyclic di-guanylate monophosphate. Biotechnology Reports, 7, 30-37 (DOI: 10.1016/j.btre.2015.04.008).
34. Lahiri, T.; Luan, B.; Raleigh, D.P.; Boon, E.M.* (2014) A structural basis for the regulation of an H-NOX-associated cyclic-di-GMP synthase/phosphodiesterase enzyme by nitric oxide-bound H-NOX. Biochemistry, 53, 2126-2135 (DOI: 10.1021/bi401597m).
33. Henares, B.M.; Xu, Y.; Boon, E.M.* (2013) A nitric oxide-responsive quorum sensing circuit in Vibrio harveyi regulates flagella production and biofilm formation. The International Journal of Molecular Sciences, 14, 16473-16484 (DOI: 10.3390/ijms140816473).
**This was included in a special issue entitled Quorum Sensing Research in Microbial Systems.
32. Kosowicz, J.G.; Boon, E.M.* (2013) Insights into the distal pocket of H-NOX using fluoride as a probe for H-bonding interactions. Journal of Inorganic Biochemistry, 126, 91-95 (DOI: 10.1016/j.jinorgbio.2013.05.012).
31. Arora, D.P.; Boon, E.M.* (2013) Unexpected biotinylation using ATP-γ-Biotin-LC-PEO-amine as a kinase substrate. Biochemical and Biophysical Research Communications, 432, 287-290 (DOI: 10.1016/j.bbrc.2013.01.115).
30. Henares, B.M.; Higgins, K.E.; Boon, E.M.* (2012) Discovery of a nitric oxide-responsive quorum sensing circuit in Vibrio harveyi. American Chemical Society Chemical Biology, 7, 1331-1336 (DOI: 10.1021/cb300215t).
**Featured in Chemical & Engineering News (http://cen.acs.org/articles/90/web/2012/05/Nitric-Oxide-Regulates-Group-Behavior.html) and the ACS Chemical Biology podcast (volume 7, episode 8)
29. Arora, D.P.; Boon, E.M.* (2012) Nitric oxide regulated two-component signaling in Pseudoalteromonas atlantica. Biochemical and Biophysical Research Communications, 421, 521-526 (DOI: 10.1016/j.bbrc.2012.04.037).
28. Liu, N.; Xu, Y.; Hossain, S.; Huang, N.; Coursolle, D.; Gralnick, J.; Boon, E.M.* (2012) Nitric oxide regulation of cyclic di-GMP synthesis and hydrolysis in Shewanella woodyi. Biochemistry, 51, 2087-2099 (DOI: 10.1021/bi201753f).
**Cited by the Faculty of 1000 (http://f1000.com/714897822).
27. Dai, Z.; Farquhar, E.R.; Arora, D.P.; Boon, E.M.* (2012) Is histidine dissociation a critical component of the NO/H-NOX signaling mechanism? Insights from X-ray absorbance spectroscopy. Dalton Transactions, 41, 7984-7993 (DOI: 10.1039/C2DT30147D). PMCID: PMC3671924
**This was included in a special issue highlighting the work of young scientists.
26. Muralidharan, S.; Boon, E.M.* (2012) Heme flattening is sufficient for signal transduction in the H-NOX family. Journal of the American Chemical Society, 134, 2044-2046 (DOI: 10.1021/ja211576b).
25. Dai, Z.; Boon, E.M.* (2011) Probing the local electronic and geometric properties of the heme iron center in an H-NOX domain. Journal of Inorganic Biochemistry, 105, 784-792 (DOI: 10.1016/j.jinorgbio.2011.03.002). PMCID: PMC3137124
24. Tran, R.; Weinert, E.E.; Boon, E.M.; Mathies, R.A.; Marletta, M.A. (2011) Determinants of the heme-CO vibrational modes in the H-NOX family. Biochemistry, 50, 6519-6530.
23. Dai, Z.; Boon, E.M.* (2010) Engineering of the heme pocket of an H-NOX domain for direct cyanide detection and quantification. Journal of the American Chemical Society, 132, 11496-11503 (DOI: 10.1021/ja101674z).
22. Liu, N.; Pak, T.; Boon, E.M.* (2010) Characterization of a diguanylate cyclase from Shewanella woodyi with cyclase and phosphodiesterase activities. Molecular BioSystems, 6, 1561-1564 (DOI: 10.1039/c002246b).
**This was included in a special issue highlighting the work of emerging investigators.
21. Tran, R.; Boon, E.M.; Marletta, M.A.; Mathies, R.A. (2009) Resonance Raman spectra of an O2-binding H-NOX domain reveals heme relaxation upon mutation. Biochemistry, 48, 8568-8577.
20. Olea, C.; Boon, E.M.; Pellicena, P.; Kuriyan, J.; Marletta, M.A. (2008) Probing the function of heme distortion in the H-NOX family. American Chemical Society Chemical Biology, 3, 703-710.
19. Boon, E.M.; Marletta, M.A. (2006) Sensitive and selective detection of nitric oxide using an H-NOX domain. Journal of the American Chemical Society, 128, 10022-10023.
18. Boon, E.M.; Davis, J.H.; Karow, D.S.; Huang, S.H.; Tran, R.; Miazgowicz, M.M.; Mathies, R.; Marletta, M.A. (2006) Nitric oxide binding to prokaryotic homologs of the soluble guanylate cyclase b1 H-NOX domain. Journal of Biological Chemistry, 281, 21892-21902.
17. Boon, E.M.; Marletta, M.A. (2005) Ligand discrimination in soluble guanylate cyclase and the H-NOX family of heme sensor proteins. Current Opinion in Chemical Biology, 9, 441-446.
16. Boon, E.M.; Huang, S.H.; Marletta, M.A. (2005) A molecular basis for NO selectivity in soluble guanylate cyclase. Nature Chemical Biology, 1, 53-59.
15. Boon, E.M.; Marletta, M.A. (2005) Ligand specificity of H-NOX domains: From sGC to bacterial NO sensors. Journal of Inorganic Biochemistry, 99, 892-902.
14. Yavin, E.; Boal, A.K.; Stemp, E.D.A.; Boon, E.M.; O’Shea, V.L.; David, S.S.; Barton, J.K. (2005) Protein-DNA charge transport: Redox activation of a DNA repair protein by guanine radical. Proceedings of the National Academy of Science USA, 102, 3546-3551.
13. Pellicena, P.; Karow, D.S.; Boon, E.M.; Marletta, M.A.; Kuriyan, J. (2004) Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases. Proceedings of the National Academy of Science USA, 101, 12854-12859.
**Cited by the Faculty of 1000 (http://f1000.com/1020824).
12. Boon, E.M.; Barton, J.K. (2003) DNA electrochemistry as a probe of base pair stacking in A-, B-, and Z-form DNA. Bioconjugate Chemistry, 14, 1140-1147.
11. Boon, E.M.; Barton, J.K.; Bhaghat, V.; Nersissian, M.; Wang, W.; Hill, M.G. (2003) Reduction of ferricyanide by methylene blue at a DNA-modified rotating-disk electrode. Langmuir, 19, 9255-9259.
10. Boon, E.M.; Livingston, A.L.; Chmiel, N.H.; David, S.S.; Barton, J.K. (2003) DNA-mediated charge transport for DNA repair. Proceedings of the National Academy of Science USA, 100, 12543-12547.
9. Boon, E.M.; Jackson, N.M.; Wightman, M.D.; Kelley, S.O.; Hill, M.G.; Barton, J.K. (2003) Intercalative stacking: A critical feature of DNA charge transport electrochemistry. Journal of Physical Chemistry B, 107, 11805-11812.
8. Boon, E.M.; Kisko, J.L.; Barton, J.K. (2002) Detection of base mismatches using intercalators. Methods in Enzymology, 353, 506-522.
7. Boon, E.M.; Barton, J.K. (2002) Charge transport in DNA. Current Opinion in Structural Biology, 12, 320-329.
6. Boon, E.M.; Barton, J.K.; Pradeepkumar, P.I.; Isaksson, J.; Petit, C.; Chattopadhyaya, J. (2002) An electrochemical probe of DNA stacking in an antisense oligonucleotide containing a C3’-endo locked sugar. Angewandte Chemie International Edition, 114, 3552-3555.
5. Boon, E.M.; Pope, M.A.; Williams, S.D.; David, S.S.; Barton, J.K. (2002) DNA-mediated charge transport as a probe of MutY/DNA interaction. Biochemistry, 41, 8464-8470.
4. Boon, E.M.; Salas, J.E.; Barton, J.K. (2002) An electrical probe of DNA-protein interactions on DNA-modified surfaces. Nature Biotechnology, 20, 282-286.
3. Sam, M.†; Boon, E.M.†; Barton, J.K.; Hill M.G.; Spain, E. (2001) Morphology of 15-mer duplexes tethered to Au(111) through 3' and 5' linkages via scanning probe microscopy. Langmuir, 17, 5727-5730. †equal authorship
2. Boon, E.M.; Ceres, D.M.; Drummond, T.G.; Hill, M.G.; Barton, J.K. (2000) Mutation detection by electrocatalysis at DNA-modified electrodes. Nature Biotechnology, 18, 1096-1100.
1. Kelley, S.O.; Boon, E.M.; Barton, J.K.; Jackson, N.M.; Hill, M.G. (1999) Single base mismatch detection based on charge transduction through DNA. Nucleic Acids Research, 27, 4830-4837.
Patents
5. Nesbitt, N.M.; Johnson, R.A.; Boon, E.M. (2012) Engineering of a bi-functional diguanylate cyclase-phosphodiesterase to improve the enzymatic production of cyclic-di-GMP. Patent disclosure submitted, Research Foundation reference number R-8501.
4. Cary, S.P.L.; Boon, E.M.; Weinert, E.E.; Winger, J.; Marletta, M.A. (2007) Compositions and methods for the delivery of oxygen. Patent number US 9,493,526 issued November 15, 2016. PCT Int. Appl. WO/2007/139791.
3. Cary, S.P.L.; Boon, E.M.; Winger, J.; Marletta, M.A. (2007) Compositions and methods for the delivery of nitric oxide. Patent number US 9,493,527 issued November 15, 2016. PCT Int. Appl. WO/2007/139767.
2. Boon, E.M.; Marletta, M.A. (2005) Sensitive and selective detection of NO using an H-NOX domain. Patent disclosure submitted, UC case number B06-064.
1. Barton, J.K.; Boon, E.M.; Kelley, S.O.; Hill, M.G. (2001) Electrochemical sensor using intercalative, redox-active moieties. PCT Int. Appl. WO/2003/023365.
Book Chapters
3. Williams, D.E.; Fischer, J.T.; Heckler, I.L.; Boon, E.M.* (2018) Haem-based sensors of nitric oxide. In Gas Sensing in Cells, 15-36. Aono, S., ed., London, United Kingdom: The Royal Society of Chemistry (DOI: 10.1039/9781788012836).
2. Arora, D.P.; Muralidharan, S.; Boon, E.M.* (2016) NO/H-NOX-regulated two-component signaling. In Stress and Environmental Control of Gene Expression in Bacteria, 268-276. de Bruijn, F.J., ed. Hoboken, NJ: Wiley-Blackwell.
1. Boon, E.M.*; Muralidharan. S. (2014) The biological relevance of metal complexes of nitric oxide. In Yearbook of Science and Technology, 34-38. New York, NY: McGraw-Hill.